Elara Flat

Photobioreactors

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ELARA Flat photobioreactors are ideal for phototrophic organisms like moss, microalgae, bacteria and plant cells. The Flat design allows much higher light intensity control by utilizing uni-directional light source & receiver. The light intensity is dimmable from 0-100% up to 3000 μmol(photon)/m2. Available luminostat mode via radiation sensor.

Learn more about photobioreactors: Photobioreactors and optimizing your phototrophic bioprocess

Product Details

Benefits

Benefits of Solaris Elara Flat Bioreactors

Photobioreactors

Digital online DO, pH, conductivity, &/or ORP sensor management utilizing Hamilton ARC Modbus communication.
Peristaltic pump options for feed, pH control, etc.
Up to 5 mass flow controllers within PCS cube.
Powerful & Intuitive Leonardo Software to control up to 24 units in parallel.
Flexible options for data export & management.
Remote control access available via PC, tablet and/or smartphone.
Asymmetric shape to prevent foam formation
Homogeneous light distribution through innovative flat design.
Automatic and manual control of light intensity and circadian cycle simulation.
Safety pressure relief valve included
Compact and modular PCS (350x350x350 mm)
Additional options include optical density, dCO2, weight, Thermobox, etc.
Process contact materials are borosilicate glass and Super duplex SAF 2507; highly resistant to salty water.
Airlift gas mixing design

Sensors

Modbus Hamilton Sensors

Why a digital sensor?

Hamilton sensors (including Cell Density products) have been digitally integrated to the Solaris PCS and Leonardo controlling software giving the user many benefits over traditional analog sensor outputs.

probe details

Such benefits include:

More robust communication protocol not susceptible to noise.
Sensor diagnostic & health information available within controlling software.
Calibration time greatly reduced & simplified through parallel calibrations & batch calibrations - only possible with digital "smart" sensors.
Real time sensor warnings/errors which can help eliminate lost batches due to probes fouling mid-run.

pH

The Easyferm Family boasts a durable long lasting reference system utilizing pre-pressurized electrolyte. The Everef-F reference cartridge ensures that the reference electrolyte remains free of silver and precipitation of proteins resulting in more life in terms of sterilization cycles. ARC technology allows calibration memory - eliminating mV calibration to the controller, as well as real time sensor diagnostics.

DO2

VisiFerm was the first online optical dissolved oxygen sensor in the market. Optical DO sensors require much less maintenance than classical polarographic/electrochemical sensors utilizing membranes & electrolyte. ARC technology allows calibration memory - eliminating nA/mA calibration to the controller, as well as real time sensor diagnostics including optical cap life, etc.

ORP

Like pH, the Easyferm ORP sensor family also utilizes a a pre-pressurized reference electrolyte enabling clogfree diaphragm technology. The sensor ensures a stable measurement even after steam sterilization, autoclave and CIP cleanings. ARC technology allows calibration memory - eliminating mV calibration to the controller, as well as real time sensor diagnostics.

CONDUCTIVITY

All conductivity wetted parts are FDA approved, & are designed to withstand SIP/CIP and/or autoclave sterilization. Hamilton conductivity sensors display very good linearity over a broad measuring range.

OPTICAL DENSITY

Online optical density measurement relative to cell growth
Real time trending allows better process understanding & early detection of process deviations

Hamilton Dencytee gives information relative to total cell density in solution. The sensor is based on optical density, which measures the turbidity of cells in suspension. The measurement is made at NIR (near-infra red) wavelengths & thus insensitive to changes in media color. All particles and molecules that scatter light at 880 nm will be detected, including living and dead cells as well as cell debris. This measurement is effective after inoculation when cells are expanding quickly but concentrations are low, making capacitance-based readings less reliable.

VIABLE CELL DENSITY - PERMITTIVITY

Online & real time viable cell density information relative to permittivity/capacitance output.
Frequency Scanning available for further data generation & analytical correlations, i.e. detecting changes in cell physiology
Brings great efficiency to product development.
Uses include optimizing feed & process strategies, automating continuous feed/harvest processes, detecting process deviations, etc.

Incyte sensor enables real-time, online measurement of viable cells in solution. The measurement is not influenced by changes in the media, microcarriers, dead cells or debris, and is designed for mammalian cell culture, yeast and high-density bacterial fermentation. Online measurement of viable cells makes it possible to detect events and respond in real time without sampling.

Sampling

LEDA Sampling System

LEDA single use sterile sampling system enables up to 180 sterile samples per run.
The needlefree connector is designed to reduce the risk of contamination during sampling.

Technical specifications
Material	VALOX resin (external) silicone (internal)
Autoclavable	121-133°C (up to 30 minutes)
Residual volume	0.04 mL
Flow rate	65 mL/minute

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Gas Mixing

Gas Mixing with Elara Flat Photobioreactor

Various controller and hardware configurations enable aeration strategies using air, oxygen, nitrogen or a mixture. Utilization of mass-flow controllers allow the exact flow rate control of individual gases. The flexible aeration options integrated in the photobioreactor allow wide range experimental design versatility.

gas mixing

1 Thermal Mass Flow Controller in base unit
Gas mixing through up to 5 TMFC or utilizing solenoid valves.
Automatic gas mixing algorithms available.
Toro, fluted, and sintered spargers available.

Cube Series

Solaris Cube Series

Why a cube?

Solaris’ modular product design strategy decreases the number of unique parts which reduces time of production. The result is a lean, smart, compact & flexible PCS.

modular boxes

Software

User-friendly Software

Solaris controlling software offers a simply laid out, yet powerful platform for experimental design planning and process control. The graphical user interface enables the intuitive selection & adjustment of control functions.

Extracted data is compatible with Window Excel, but in addition, Solaris offers a platform where fermentation data can be easily exported in real time & thus managed. This software is included in supply and can be installed on an unlimited number of the client’s PC or laptops.

Features

Home screen with Multi-level password protection.
Synoptic page also allowing manual operation of components (pumps, valves etc.)
Controller page allows easy access to setpoints, current values, control modes, PID customi-zation, alarm limits, etc.
SBC-16 manages process phases such as: stand by phase (free use, maintenance); pre-cultivation phase (automatically entered after sterilization, managing the pre-innoculum); and cultivation phase.
Trends page allows real time process variable monitoring, comparison, data export, etc. On the graphical interface, up to 6 process and/or set point variables can be viewed simultaneously. Dynamic zooms and graphical configurations within set time frames can be changed interactively.

Solaris Fermentation Manager

Extracted data is compatible with Windows Excel, however, Solaris has also developed a platform where fermentation data can be easily exported in real time & thus managed in various protocols.

Solaris Logic Parser

The Solaris Logic Parser plug-in, integrated to SBC-16 as standard, gives users the additional capability of customized control by relating all available process variables with common conditional statements.